CPMV-DOX Delivers

Kinesin Delivers

What is it about movement in cells that commands our atten-tion? What biologist has not enjoyed turning a microscope on a cell, almost any cell, really, and watching all the commo-tion? When vesicles, mitochondria, chloroplasts, nuclei, or chromosomes move, we are being treated to an elegant, easily observable manifestation of molecular events. Decades of effort to understand intracellular move...

Tsien Delivers Falk Lecture

1993 Falk Memorial Lecture. (left to right) Lecture coordinator Elizabeth Murphy; lecturer Roger Y. Tsien; Director Kenneth Olden; Falk's widow, Gabrielle Falk; Falk's son, Donald H. Falk; and Falk's sister, Eva Wulkan. account for only 15% of all colorectal cancers, it is likely that both inheritance and environmental factors play important roles in the pathogenesis of this disease. Scientists...

KIF16B delivers for transcytosis.

Protein sorting pathways control correct delivery of membrane proteins to specific compartments of the plasma membrane and are required to maintain the physiological functions in all epithelia. Most clathrindependent cargoes require the adaptor protein complexes AP-1A and AP-1B for proper sorting to the basolateral plasma membrane. In this issue of The EMBO Journal, Perez Bay et al (2013) shed ...

The CMMISM Project Delivers

Endothelial Targeting of Cowpea Mosaic Virus (CPMV) via Surface Vimentin

Cowpea mosaic virus (CPMV) is a plant comovirus in the picornavirus superfamily, and is used for a wide variety of biomedical and material science applications. Although its replication is restricted to plants, CPMV binds to and enters mammalian cells, including endothelial cells and particularly tumor neovascular endothelium in vivo. This natural capacity has lead to the use of CPMV as a senso...